Lab Publications
Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis
Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis
Christopher S. Campomizzi, Patil Pranita Uttamrao, Jack J. Stallone, Thenmalarchelvi Rathinavelan, D. Fernando Estrada
Christopher S. Campomizzi, Patil Pranita Uttamrao, Jack J. Stallone, Thenmalarchelvi Rathinavelan, D. Fernando Estrada
2024, Biochemistry
Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail
Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail
Natalie Jay, Janie E. McGlohon, D. Fernando Estrada
Natalie Jay, Janie E. McGlohon, D. Fernando Estrada
2023, Journal of Inorganic Biochemistry
Structural basis of bidirectional allostery across the heme in a cytochrome P450 enzyme
Structural basis of bidirectional allostery across the heme in a cytochrome P450 enzyme
Amit Kumar & D. Fernando Estrada
Amit Kumar & D. Fernando Estrada
2023, Journal of Biological Chemistry
Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of Mycobacterium tuberculosis
Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of Mycobacterium tuberculosis
Christopher S. Campomizzi, Amit Kumar, Patil Pranita Uttamrao, Jack J. Stallone, George E. Chanatios, Thenmalarchelvi Rathinavelan, and D. Fernando Estrada
Christopher S. Campomizzi, Amit Kumar, Patil Pranita Uttamrao, Jack J. Stallone, George E. Chanatios, Thenmalarchelvi Rathinavelan, and D. Fernando Estrada
2023, ACS Infectious Diseases
Collaborative publication with Simons lab:
Collaborative publication with Simons lab:
Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors
Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors
Lama A. Alshabini, Amit Kumar, Sam J. Willcocks, Gayathri Srithiran, Sanjib Bhakta, D. Fernando Estrada, and Claire simons
Lama A. Alshabini, Amit Kumar, Sam J. Willcocks, Gayathri Srithiran, Sanjib Bhakta, D. Fernando Estrada, and Claire simons
2022, RSC Medicinal Chemistry
Characterization of a cleavable fusion of human CYP24A1 with Adrenodoxin reveals the variable role of hydrophobics in redox partner binding
Characterization of a cleavable fusion of human CYP24A1 with Adrenodoxin reveals the variable role of hydrophobics in redox partner binding
Natalie Jay, Sean R. Duffy, D. Fernando Estrada
2022, Biochemistry
19F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis
19F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis
Christopher S. Campomizzi, George E. Ghanatios, D. Fernando Estrada
2021, Journal of Biological Chemistry
Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis
Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis
Amit Kumar, Christopher S. Campomizzi, Natalie Jay, Shaun Ferguson, Emelie-Jo Scheffler, James Lioi, Chengjian Tu, Jun Qu, Claire Simons, D. Fernando Estrada
2021, Scientific Reports
Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1
Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1
Amit Kumar, P. Ross Wilderman, Chengjian Tu, Shichen Shen, Jun Qu, D. Fernando Estrada
2020, Biochemistry
Specificity of the redox complex between cytochrome P450 24A1 and Adrenodoxin relies on carbon-25 hydroxylation of vitamin-D substrate
Specificity of the redox complex between cytochrome P450 24A1 and Adrenodoxin relies on carbon-25 hydroxylation of vitamin-D substrate
Amit Kumar & D. Fernando Estrada
2019, Drug Metabolism and Disposition
The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species
The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species
D. Fernando Estrada
2018, Journal of Biological Chemistry