Lab Publications

Characterization of a cleavable fusion of human CYP24A1 with Adrenodoxin reveals the variable role of hydrophobics in redox partner binding

Natalie Jay, Sean R. Duffy, D. Fernando Estrada

2022, Biochemistry, In Press

19F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis

Christopher S. Campomizzi, George E. Ghanatios, D. Fernando Estrada

2021, Journal of Biological Chemistry



Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis

Amit Kumar, Christopher S. Campomizzi, Natalie Jay, Shaun Ferguson, Emelie-Jo Scheffler, James Lioi, Chengjian Tu, Jun Qu, Claire Simons, D. Fernando Estrada

2021, Scientific Reports



Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1

Amit Kumar, P. Ross Wilderman, Chengjian Tu, Shichen Shen, Jun Qu, D. Fernando Estrada

2020, Biochemistry


Specificity of the redox complex between cytochrome P450 24A1 and adrenodoxin relies on carbon-25 hydroxylation of vitamin-D substrate

Amit Kumar & D. Fernando Estrada

2019, Drug Metabolism and Disposition


The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species

D. Fernando Estrada

2018, Journal of Biological Chemistry