We are a research laboratory in the Biochemistry Department at the Jacobs School of Medicine and Biomedical Sciences in Buffalo, NY.
The goal of our research is to understand how the protein structures of cytochrome P450 enzymes relate to their function. As a lab, we are motivated by an appreciation that structural regulation in Class-I P450 enzymes is not well understood. These include all P450 enzymes that function in the inner mitochondrial membrane as well as most bacterial P450.
Current projects include an on-going investigation of the enzymes that are necessary for vitamin-D metabolism as well as the Mycobacterial enzyme CYP121.
Trainees joining our lab will gain experience in protein expression and purification, ultraviolet and visible wavelength spectroscopy, biolayer interferometry, and nuclear magnetic resonance spectroscopy.